LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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206 entries where LYS is found as a standalone ligand73 entries where LYS is covalently linked to polymer or other heterogen groups 245,804 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00123
Name	Lysine
Groups	investigational approved nutraceutical
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	(S)-α,ε-diaminocaproic acid Lysinum 6-ammonio-L-norleucine Lysine acetate LYS L-Lysin Lysina Lysine acid Lysine hydrochloride L-2,6-Diaminocaproic acid Lysine monohydrate Lysine dihydrate L-Lysine (S)-2,6-diaminohexanoic acid L-lys Lysine (S)-lysine
Brand Names	5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn-PF 8.5% Freamine III 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Travasol 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn-PF 10% 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Aminosyn Sulfite Free Clinimix Nephramine Liq IV ProSol Aminosyn II in Dextrose 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Smofkabiven Aminosyn II 7% With 10% Dextrose Aminosyn 7% Smofkabiven Extra Nitrogen Electrolyte Free 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 4.4% HepatAmine Aminosyn II with Electrolytes in Dextrose with Calcium Vamin N Aminosyn 8.5% Aminosyn RF Lysakare Smofkabiven Peripheral 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Essepna 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn 5% Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Smofkabiven Extra Nitrogen Aminosyn RF Injection Hepatasol Synthamin Aminosyn II 7% M In 10% Dextrose(dual Chamber) RenAmin 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Effervescent Potassium Chloride Travasol Amino Acid Inj 8.5% Olimel 4.4% E Olimel 7.6% E ProcalAmine Aminosyn 10% W Electrolytes Olimel 7.6% Olimel 5.7% Aminosyn HF Aminosyn II 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II with Electrolytes Kabiven Clinisol Xyzmune 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn II 7% Injection Aminosyn II 5% Inj Primene 10%-liq IV Nutrineal Pd4 FreAmine III Aminosyn II 8.5% Injection 4.25%travasol Amino Acid InJ.W.elecw.5%dex. 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 20% Prosol Travasol E 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn II In Dextrose Injection Aminosyn II 10% With Electrolytes Imubolic Olimel 5.7% E Novamine Aminosyn 3.5% M Renamin (amino Acids) Injection Aminosyn 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Travasol Inj Without Electrolytes 5.5% Aminosyn 8.5% Injection With Electrolytes 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Primene 10% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Travasol Inj Without Electrolytes 8.5% Olimel 3.3% E Aminosyn-PF 7% Aminosyn II and Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose TrophAmine Plenamine Stye Eye Relief Serum 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Primene Vamin 18 Electrolyte-free Perikabiven Periolimel 2.5% E Travasol Amino Acid Inj 5.5% FreAmine HBC Clinimix E Smofkabiven Electrolyte Free 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. NephrAmine 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Aminosyn II 7% With 50% Dextrose Aminosyn II 8.5% With 50% Dextrose
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682